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Abstract #3622

Quantification of Brain Perfusion in Patients with Internal Carotid Stenosis and Perfusion Change After Carotid Stenting Based on Dynamic Susceptibility Contrast-Enhanced MRI

Mao-Yuan Su1, H-L Kao2, Y-W Wu2, H-Y Yu3, W-C Chu, W-Y Isaac Tseng4

1Institute of Biomedical Engineering, Natioanl Yang-Ming University, Taipei, Taiwan; 2Internal Medicine, National Taiwan University Hospital; 3Surgery, Natioanl Taiwan University Hospital; 4Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine

In patients with internal carotid artery (ICA) stenosis, the risk of stroke is associated with reduction of brain perfusion. To reduce the risk, carotid stenting has been considered a treatment of choice. The change in the brain perfusion after stenting, however, still remains unclear. In this study, we used dynamic susceptibility contrast-enhanced MRI to measure brain perfusion change post carotid stenting. In six patients with ICA stenosis, mean transit time (MTT) showed the most significant change, followed by cerebral blood volume (CBV) in the hemispheres ipsilateral to the ICA stenosis. These abnormal perfusion indices returned to normal after carotid stenting.