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Abstract #3629

Performance of Pseudo-Continuous Arterial Spin Labeling in the Estimation of Fractional Changes in CBF with Activation: Comparison with QUIPSS II

Wen-Ming Luh1, Eric C. Wong2, Peter A. Bandettini1

1FMRIF, NIMH, NIH, Bethesda, MD, USA; 2Departments of Radiology and Psychiatry, University of California, San Diego, La Jolla, CA, USA

Arterial spin labeling (ASL) techniques have been applied to functional studies to estimate cerebral blood flow (CBF) changes during brain activation and in turn to estimate the cerebral metabolic rate of oxygen. Both QUIPSS II and continuous ASL (CASL) with a post-tagging delay are designed to be insensitive to changes in transit delay. In this study, we compare the fractional signal changes with motor activation using UIPSS II, and Pseudo CASL.