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Abstract #3641

Can Arterial Spin Labeling Be Used to Identify Perfusion Distribution Differences Using Group Analysis?

Dennis Armand Kies1, Julien R. Milles2, Wouter M. Teeuwisse1,3, Johan R.C. Reiber2, Andrew Webb1,3, Mark A. Van Buchem1,3, Matthias J.P. Van Osch1,3

1Radiology, Leiden University Medical Center, Leiden, Netherlands; 2LKEB, Leiden University Medical Center, Leiden, Netherlands; 3C.J. Gorter Center for High Field MRI, Leiden, Netherlands

Arterial spin labeling provides a completely non-invasive tool for quantitative measurement of CBF and can therefore easily be added to clinical research protocols. Most frequently a voxel-based morphometry-like analysis method is employed to identify differences in the perfusion distribution between a patient and control group. How well such a procedure is able to detect differences in perfusion patterns is unknown. This is evaluated by using neuronal activation to achieve CBF changes. This yields a gold standard (rest minus activation per subject) as well as the outcome of a group analysis (rest scans of group A versus activation of group B).