Dennis Armand Kies1, Julien R. Milles2, Wouter M. Teeuwisse1,3, Johan R.C. Reiber2, Andrew Webb1,3, Mark A. Van Buchem1,3, Matthias J.P. Van Osch1,3
1Radiology, Leiden University Medical Center, Leiden, Netherlands; 2LKEB, Leiden University Medical Center, Leiden, Netherlands; 3C.J. Gorter Center for High Field MRI, Leiden, Netherlands
Arterial spin labeling provides a completely non-invasive tool for quantitative measurement of CBF and can therefore easily be added to clinical research protocols. Most frequently a voxel-based morphometry-like analysis method is employed to identify differences in the perfusion distribution between a patient and control group. How well such a procedure is able to detect differences in perfusion patterns is unknown. This is evaluated by using neuronal activation to achieve CBF changes. This yields a gold standard (rest minus activation per subject) as well as the outcome of a group analysis (rest scans of group A versus activation of group B).