Estimation of Pure Gray Matter Perfusion Using Pseudo-Continuous Arterial Spin Labeling and Partial Volume Correction

Wen-Ming Luh¹, Peter A. Bandettini¹

With typical spatial resolution used in MR perfusion imaging, the number of 100% GM voxels is very small with folding cortical layers of about 2-4mm thick. Therefore it is important to take partial volume effects (PVE) into account for quantifying measured cerebral blood flow in the human brain as well as for comparison to animal models with little PVE. Here a strategy is proposed to correct for PVE with arterial spin labeling (ASL) measurements using pseudo-continuous ASL.