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Abstract #3721

BOLD Impulse Response Functions in the Somatosensory Cortex: Implications for CMRO2 Calculation

Peter Herman1,2, Basavaraju G. Sanganahalli1, Hal Blumenfeld3,4, Fahmeed Hyder1,5

1Diagnostic Radiology, Yale University, New Haven, CT, USA; 2Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary; 3Neurology, Yale University, New Haven, CT, USA; 4Neurobiology, Yale University, New Haven, CT, USA; 5Biomedical Engineering, Yale University, New Haven, CT, USA

Quantitative mapping of changes in CMRO2 with BOLD calibration has become a popular modality for studying functional brain activity with different somatosensory stimulations. CMRO2 calculation requires multi-modal measurements of BOLD, CBV, CBF and/or neural activity, which can vary in different areas of the somatosensory cortex. We measured BOLD and LFP responses in the forelimb and the whisker barrel cortex. The amplitudes of the BOLD and LFP responses were smaller in the whisker area. We calculated BOLD impulse response functions in these areas to reveal whether or not the different BOLD responses can be explained by the different neural responses.