Abstract #3736

Detecting Clinically Significant Subtle Myocardial Damage in Myocardial Infarction Using Multi-Contrast Delayed Enhancement MRI: Correlation with Whole-Mount Heart Histology at Micron-Level Resolution

Yuesong Yang¹, Jay S. Detsky¹, Mihaela Pop¹, Alexander J. Dick¹, Graham A. Wright^1,2

¹Imaging Research, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; ²Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

Synopsis: It is very challenging to detect clinically significant subtle myocardial damage such as papillary muscle (PM) and right ventricular (RV) involvement associated with myocardial infarction (MI) by conventional MRI. PM-MI is a primary factor leading to the occurrence of mitral regurgitation and a potential source of ventricular arrhythmia. RV-MI and dysfunction are also independent indicators of poor prognosis in patients with MI. In this paper a new multi-contrast delayed enhancement (MCDE) MRI technique is used to identify these subtle myocardial damage and was correlated with whole-mount heart histology at micron-level resolution.