Abstract #3738

Myocardial Infarction Quantification and Function Assessment with Manganese Enhanced MRI (MEMRI) in Mice on a Clinical 3T Scanner

Benedicte Delattre¹, Vincent Braunersreuther², Jean-Nol Hyacinthe¹, Franois Mach², Jean-Paul Valle^1,3

¹Faculty of Medicine, University of Geneva, Geneva, Switzerland; ²Division of Cardiology, Department of Medicine, University Hospital, Foundation for Medical Researchers, Geneva, Switzerland; ³Work supported in part by the Center for Biomedical Imaging (CIBM), Geneva and Lausanne

Manganese contrast agent is an efficient marker of cell activity. It has already revealed a strong efficiency in the assessment of transmural fibrotic scar myocardial infarction in mice model of permanent ligation. We demonstrate the feasibility of accurate infarct volume quantification by Manganese Enhanced MRI (MEMRI) and infarct related function deficit detection in a model of coronary occlusion reperfusion in mice, which leads to non transmural infarction. The protocol was validated on a clinical 3T scanner, a widely available platform.