Abstract #3762

Myocardial Fibro-Fatty Infiltration in Duchenne Muscular Dystrophy Canine Model Detected Using Multi-Echo Dixon Method of Water and Fat Separation Imaging

Peter Kellman¹, Diego Hernando², Saurabh Shah³, Robert F. Hoyt, Jr.¹, Robert M. Kotin¹, Bruce W. Keene⁴, Joe N. Kornegay⁵, Anthony H. Aletras¹, Andrew E. Arai¹

¹National Institutes of Health, Bethesda, MD, USA; ²University of Illinois, Urbana, IL, USA; ³Siemens Medical Solutions, Chicago, IL, USA; ⁴College of Veterinary Medicine, North Carolina State University, NC, USA; ⁵School of Medicine, University of North Carolina, Chapel Hill, NC, USA

Cardiac magnetic resonance using a multi-echo Dixon fat and water separation method was used to image fibro-fatty infiltration in the myocardium in dogs with Duchenne Muscular Dystrophy. Inducibility of arrhythmias in patients with DMD has been reported to correlate with fatty infiltration. The multi-echo Dixon method for fat and water separation provides a sensitive means of detecting small concentrations of fat with improved contrast.