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Abstract #3762

Myocardial Fibro-Fatty Infiltration in Duchenne Muscular Dystrophy Canine Model Detected Using Multi-Echo Dixon Method of Water and Fat Separation Imaging

Peter Kellman1, Diego Hernando2, Saurabh Shah3, Robert F. Hoyt, Jr. 1, Robert M. Kotin1, Bruce W. Keene4, Joe N. Kornegay5, Anthony H. Aletras1, Andrew E. Arai1

1National Institutes of Health, Bethesda, MD, USA; 2University of Illinois, Urbana, IL, USA; 3Siemens Medical Solutions, Chicago, IL, USA; 4College of Veterinary Medicine, North Carolina State University, NC, USA; 5School of Medicine, University of North Carolina, Chapel Hill, NC, USA

Cardiac magnetic resonance using a multi-echo Dixon fat and water separation method was used to image fibro-fatty infiltration in the myocardium in dogs with Duchenne Muscular Dystrophy. Inducibility of arrhythmias in patients with DMD has been reported to correlate with fatty infiltration. The multi-echo Dixon method for fat and water separation provides a sensitive means of detecting small concentrations of fat with improved contrast.