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Abstract #3763

Myocardial Lipid Accumulation Due to High Fat Diet in PPAR-Alpha Overexpressing Mouse Hearts Reduces Endocardial 2-D Principal Strains

Janusz H. Hankiewicz1, Natasha H. Banke1, E. Douglas Lewandowski1

1Program in Integrative Cardiac Metabolism, UIC College of Medicine, Chicago, IL, USA

Myocardial lipid content and 2D strains in the epi- and endocardium of the LV were determined, over a two week period of high fat diet, in non-transgenic mice (NTG) and a transgenic mouse model of increased myocardial lipid due to cardiac-specific overexpression of the proxisome proliferators activated nuclear receptor α (PPAR α). High-resolution cardiac tagging revealed that high fat diet reduced endocardial E1 and E2 strains in PPAR α hearts, while 1H MRS showed a 130% greater lipid content in than NTG hearts. Close correlations between lipid content and 2D strains indicate increased myocardial stiffness is a consequence of elevated myocardial lipid.