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Abstract #4022

Location Matched Histological Validation of MRI Parameters Relating to Mural Crohns Disease Activity.

Shonit Punwani1, Manuel Rodriguez-Justo1,2, Enrico De Vita1, Alan Bainbridge2, Stuart Bloom2, Steve Halligan1,2, Stuart Taylor1,2

1University College London, London, UK; 2University College London Hospital, London, UK

Disease activity in Crohn's disease is monitored based on a combination of clinical scores, biochemical markers and imaging via endoscopy and radiology. However, limitations to the accuracy of these techniques are recognised. Specific findings on MRI have been proposed as accurate markers of inflammation, but have yet to be convincingly validated. The purpose of this study was to validate proposed MR imaging features of Crohn's disease activity against a robust precision matched histopathological reference standard.