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Abstract #4045

Solid State 13C-NMR Analysis of Human Gall Bladder Stones<

K Jayalakshmi1, Kanchan Sonkar1, Anu Behari2, V. K. Kapoor2, Neeraj Sinha1

1Centre of Biomedical Magnetic Resonance, Lucknow, Uttar Pradesh, India; 2Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

The natural abundance 13C high resolution solid-state nuclear magnetic resonance (13C-NMR) spectra of gall stones from patients with Chronic Cholecystitis (CC) (n=12), Xantho-Granulomatous Cholecystitis (XGC) (n = 5) and Gall Bladder Cancer (GBC) (n = 10) show micro-structural variations of these gall stones. Significant structural differences were observed in gall stones from GBC as compared to those from CC. Gall stones from XGC showed similar structure as that of CC. Structural variations observed in GBC stones was much larger than stones from other disease type.