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Abstract #4046

Quantitative Proton MR Spectroscopy as a Biomarker of Tumor Necrosis in the Rabbit VX2 Liver Tumor

Ihab R. Kamel1, Manon Buijs, Josephina Vossen, li Pan2, Nouha Salibi2, Eleni Liapi, Christine Lorenz2, Jean-Francois H. Geschwind

1Radiology, Johns Hopkins Hospital, Baltimore, MD, USA; 2Siemens Healthcare

The aim of our animal study was to compare metabolic (quantification of tumor choline concentration) MR imaging findings to percent necrosis at pathology in rabbits bearing VX2 liver tumors. In this study choline concentration showed a relatively high correlation with tumor necrosis on pathology (R = 0.78). Thus proton MR spectroscopy may be useful to assess tumor necrosis.