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Abstract #4085

Assessment of Transporters of Gd-EOB-DTPA in Various Hepatocellular Nodules During Hepatocarcinogenesis Induced in Rat Livers

Natsuko Tsuda1, Osamu Matsui2

1Medical Affairs, Bayer Yakuhin, Ltd., Osaka, Japan; 2Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan

We investigated the difference in the organic anion transporting polypeptide 1 (oatp1) and multidrug resistance protein 2 (mrp2) activity among various differentiated HCC and HPN by laser capture microdissection (LCM) coupled with the reverse transcription polymerase chain reaction (RT-PCR) in order to predict the efficacy of Gd-EOB-DTPA enhanced MRI in the differential diagnosis of these nodules. As a result, the oatp1 activity decreased in the HCC and HPN; however, the mrp2 activity increased in HPN, and decreased in HCC. In addition, it was found that the transporter activity of the borderline legions (high grade HPN and early HCC) showed the similar transporter activity.