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Abstract #4099

Pilot Investigation of Intramyocellular and Abdominal Lipid Contents by 2D MR Spectroscopy and MRI in Patients with Type2 Diabetes and Impaired Fasting Glucose

Aparna Singhal1, Preethi Srikanthan2, Neil Wilson1, Anthony Sosa2, Sendhil Velan3, Nagesh Ragavendra1, RK S. Rathore4, Rakesh K. Gupta5, Michael Albert Thomas1

1Radiology, UCLA, Los Angeles, CA, USA; 2Endocrinology, UCLA, Los Angeles, CA, USA; 3Radiology, West Virginia University, Morgantown, WV, USA; 4IIT, Kanpur, UP, India; 5Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India

Calf muscle was investigated in 10 subjects with impaired fasting glucose or early diabetes using single-voxel-based 2D L-COSY. Correlation of MRS ratios was evaluated with carotid intimal thickness measured by ultrasonography, abdominal fat calculated using T1-weighted MRI and blood tests including hs-CRP as marker of inflammation. Various significant correlations were seen between muscle lipids and other parameters but hs-CRP did not show any significant correlations. In early stages of diabetes, intramyocellular fat deposition is closely related to the extent of atherosclerosis and insulin resistance and intracellular fat deposition is more strongly associated with insulin resistance and atherosclerosis than extracellular deposits.