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Abstract #4100

Hepatic Phosphorus Metabolite Concentrations of Patients with Type 2 Diabetes Assessed by 31P 3D MRSI

Marek Chmelik1,2, Albrecht Ingo Schmid1, Stephan Gruber1,3, Wolfgang Bogner1,3, Julia Szendroedi4, Martin Krssak1,3, Siegfried Trattnig1,3, Ewald Moser1,5, Michael Roden4,6

1MR Centre of Excellence, Medical University of Vienna, Vienna, Austria; 2Karl-Landsteiner Institute for Endocrinology and Metabolism, Vienna, Austria; 3Department of Radiology, Medical University of Vienna, Vienna, Austria; 4Institute for Clinical Diabetology, German Diabetes Center, Dusseldorf, Germany; 5Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria; 6Department of Medicine/Metabolic Diseases, Heinrich Heine University , Dusseldorf, Germany

Non-alcoholic fatty liver in insulin-resistant and/or type 2 diabetic patients (T2DM) can be underlain by abnormalities in energy metabolism. The purpose of this study was to apply recently developed protocol and asses in vivo hepatic phosphorus metabolite concentrations of patients with T2DM and their age and BMI-matched controls (mCON). T2DM had 23% and 20% lower Pi and g-ATP than mCON, whereas mCON had comparable concentrations than recently published young healthy volunteers. The reduction of energy metabolites could be explained by abnormalities in hepatic mitochondrial function and insulin resistance of T2DM patients.