Yoshinori Kusakabe1, Yasuyoshi Inoue1, Koji Okada1, Youichi Yamazaki1, Kenya Murase1
1Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
The purpose of this study is to develop a method for measuring the dynamics of oxygen consumption in the kidney using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI). The BOLD MRI studies were performed in anesthetized Sprague-Dawley rats. To investigate the effects of diuretics on the oxygen consumption in the kidney, we administered saline, furosemide, acetazoramide, or mannitol as diuretics. When furosemide was administered, there was a significant change in oxygen consumption in the medulla compared to that in the control group. Our method appears to be useful for measuring the dynamics of oxygen consumption in the kidney.
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