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Abstract #4156

Osteoblastic and Angiogenic Reactions in Prostate Cancer Bone Metastasis Models Studied by Macromolecular DCE-MRI and μCT

Hagit Dafni1, Andrew J. Burghardt1, Sharmila Majumdar1, Nora M. Navone2, Sabrina M. Ronen1

1Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; 2Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Angiogenesis, osteolytic and osteoblastic reactions of prostate cancer bone metastases models were studied by in-vivo macromolecular DCE-MRI and ex-vivo μCT. The osteolytic model showed only peripheral extravasation of macromolecules whereas the osteoblastic model had leaky blood vessels throughout the tumor, probably due to stromal and structural support that maintain lower tumor intersitial fluid pressure. Osteolysis was detected in both models but osteogenesis was observed only in the osteoblastic one. Thus μCT indicates bone formation and resorption but macromolecular DCE-MRI also provides structural information, and serves as a method to monitor tumor interaction with stromal cells and response to antivascular treatment.