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Abstract #4157

A Dual Modality System for Simultaneous Monitoring of a Bi-Functional Optical & MRI Contrast Agent for Cancer Detection

Yuting Lin1, Mehmet B. Unlu1, Brian Grimmond2, Anup Sood2, Egidijus E. Uzgiris3, Orhan Nalcioglu1, Gultekin Gulsen1

1Center for functional onco imaging, University of California, Irvine, CA, USA; 2GE Global Research, Niskayuna, NY, USA; 3Rensselaer Polytechnic Institute, Troy, NY, USA

Multi-modality imaging is becoming a trend in developing new generation in vivo imaging techniques for diagnosis. Recently, our group has developed a hybrid MRI/DOT multi-modality imaging system. In such a multi-modality system, each modality measures a different parameter set, which make it difficult to cross-validate the parameters measured by different modalities. An alternative solution is using a bi-functional contrast agent that provides contrast for both optical and MRI simultaneously. Here, our in vivo small animal study is the first to validate a true multi-modality system with a true multi-modality contrast agent.