Changes in High Spectral and Spatial Resolution Images of Murine Mammary Tumors Due to the Introduction of Carbogen

Sean Foxley¹, Marta Zamora¹, Erica Markiewicz¹, Gregory Karczmar¹

The purpose of this work was to investigate the effects of carbogen breathing in murine mammary tumors. Female SV40 TAg transgenic mice were imaged with high spectral and spatial resolution at 9.4T before and after the introduction of carbogen to the air supply. Images were produced from the peak of the water resonance in each tiny voxel and subtraction images were produced. The tumor rim and tumor center had similarly large positive and negative responses to the change in blood oxygenation due to the introduction of carbogen. Changes identified could be clinically useful for the development of improved treatment planning.