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Abstract #4185

Multiparametric Comparison of Magnetic Resonance Spectroscopy and Dynamic Contrast Enhanced Magnetic Resonance Imaging with Surgical Pathology

Daniel Jason Aaron Margolis1, Daisy Chien2, Ana Gomez, Gerhard Laub2, Timothy McClure1, Rajakumar Nagarajan1, Seong Ra3, Albert Thomas1, J. Paul Finn1, Steven Raman1

1Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2Siemens Medical Systems; 3Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA

Prostate magnetic resonance spectroscopy (MRS) and imaging with dynamic contrast enhancement (DCE) is gaining favor as method for staging prostate cancer. This study serves to determine how well each component, and how well overall, prostate MRI localizes disease within the prostate by sextant location. A combination of T2WI, ADC and washout is the most accurate, but T2WI, ADC, and percent enhancement yields fewer false positives.