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Abstract #4194

Early Detection of Radiation Response in Non-Hodgkins Lymphoma Xenografts

Seung -Cheol Lee1, Tim Jenkins2, Stephen Pickup1, Harish Poptani1, Edward J. Delikatny1, Jerry David Glickson1

1Dept of Radiology, University of Pennsylvania, Philadelphia, PA, USA; 2Dept of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA

Non-invasive detection of early treatment response is very important as it can provide information of response to specific drugs/treatment and tailor-fit treatment for individual patients. Previously we have shown in a human NHL xenograft model that lactate detected by in vivo MRS can be used as a very early marker of response to CHOP chemotherapy. As radiation therapy is also commonly used as a therapeutic regimen in NHL, we tested in vivo MRS and MRI methods to determine if the MR indices can be used as early markers of response to radiation therapy in an NHL xenograft.