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Abstract #4198

Evaluation of Vascular and Metabolic Response in a Human Breast Cancer Model Treated with Docetaxel

Line Rrstad Jensen1, Else Marie Huuse1, Tone Frost Bathen1, Pl Erik Goa2, Steinar Lundgren1,3, Ingrid Susann Gribbestad1

1Dept. of circulation and medical imaging, Norwegian University of Science and Technology, Trondheim, Norway; 2Dept. of radiology, St. Olav's University Hospital, Trondheim, Norway; 3Dept. of oncology, St. Olav's University Hospital, Trondheim, Norway

Methods like DCE-MRI and MRS are valuable methods for evaluating treatment effects in handling of cancer. In this study we have investigated changes after treatment with docetaxel in human MCF7 breast xenografts. Perfusion parameters were assessed by DCE-MRI and the metabolic pattern by in vivo MRS and ex vivo HR MAS MRS, followed by multivariate analysis. This anti-microtubule drug led to an increase in perfusion parameters in the treated groups. Furthermore, in vivo MRS and HR MAS MRS revealed a significant decrease in choline levels, and a shift to more normalized metabolic pattern in the treated groups.