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Abstract #4199

In Vivo and Ex Vivo Choline Metabolite Profiles as Biomarkers for Treatment Response in Locally Advanced Human Breast Cancer

Mariann Gjervik Heldahl1, Beathe Sitter1, Tone Frost Bathen1, Maria Dung Cao1, Steinar Lundgren1,2, Ingrid Susann Gribbestad1

1Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, N\A, Norway; 2Department of Oncology, St. Olavs University Hospital, Trondheim, Norway

New biomarkers are needed to obtain more individualized patient treatment. The objective of this study was to investigate the effect of neoadjuvant chemotherapy on the level and composition of choline compounds in human breast cancer using ex vivo HR MAS and in vivo MRS. The Cho, GPC, PC and tCho metabolite concentration showed differences between responders and non-responders both before and after neoadjuvant chemotherapy. These findings were most detailed in HR MAS spectra.