Simultaneous Blood Volume and Vessel Size Imaging Technique for Localized Therapy Response Detection

Stefanie Remmele¹, Julien Sngas¹, Thorsten Persigehl², Christoph Bremer², Janine Ring²

In this work, we present a technique for time-efficient and accurate relaxometry that allows for comprehensive multi-parametric and localized insight into vascularization changes in tumor therapy follow-up studies using blood-pool agents. In a preclinical study, the response to an anti-vascular treatment was only poorly reflected by global statistical values, but manifested in how vascularization distributed over the tumor, which was adequately detected by the proposed method.