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Abstract #4203

Simultaneous Blood Volume and Vessel Size Imaging Technique for Localized Therapy Response Detection

Stefanie Remmele1, Julien Sngas1, Thorsten Persigehl2, Christoph Bremer2, Janine Ring2

1Philips Research Europe, Hamburg, Germany; 2Department of Radiology, University of Muenster, Muenster, Germany

In this work, we present a technique for time-efficient and accurate relaxometry that allows for comprehensive multi-parametric and localized insight into vascularization changes in tumor therapy follow-up studies using blood-pool agents. In a preclinical study, the response to an anti-vascular treatment was only poorly reflected by global statistical values, but manifested in how vascularization distributed over the tumor, which was adequately detected by the proposed method.