Meeting Banner
Abstract #4209

Dynamic-Contrast Enhanced MRI and MR-Guided Biopsy in the Detection of Local Recurrence After Radiation Therapy for Prostate Cancer

Derya Yakar1, Thomas Hambrock, Henkjan Huisman, Tom Scheenen, Christina Hulsbergen-vandeKaa, Emile van Lin, Jelle Barentsz, Jurgen Ftterer

1Radiology, UMC St Radboud, Nijmegen, Gelderland, Netherlands

Currently used techniques in the detection of prostate cancer recurrence after radiotherapy are inadequate. We studied the potential of Dynamic-Contrast Enhanced (DCE) MRI in combination with MR guided biopsy of tumor suspicious regions (TSR) to improve detection of local prostate cancer recurrence following radiotherapy. 15 Patients with 3 consecutive rises in prostate specific antigen (PSA) level after radiotherapy underwent MRI at 3T. TSR were determined from T2-weighted MR images and DCE-MR images. An MR-guided biopsy was taken from these TSR. Prostate cancer was found in 13/15 patients. 22/29 TSR were positive for tumor on biopsy.