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Abstract #4227

Vessel Size Index and Blood Volume Imaging in Pancreatic Cancer Xenograft Model Using Ferumoxide

Andrew C.H. Yung1, Jenny C.H. Tso1, Jennifer Flexman1, Sylvia Ng1,2, Donald Yapp1,2, Piotr Kozlowski1

1University of British Columbia, Vancouver, BC, Canada; 2British Columbia Cancer Research Centre

The use of ferumoxide is investigated for use in the blood volume fraction (BV) and vessel size index (VSI) measurements of a xenograft mouse model of pancreatic cancer. The ferumoxide susceptibility contrast remains stable for at least 1.5 hours after injection. Spectroscopy measurements produce a susceptibility value of 1.37 ppm for ferumoxide in blood. BV was well correlated with a histology measure of perfused tumour vessels, and VSI showed good correlation with BV. We show that ferumoxide can be successfully used in BV and VSI measurements.