Abstract #4228

Reproducibility and Cross-Validation of DCE-MRI and DCE-CT Perfusion Parameters in a Rat Tumor Model

Chaan S. Ng¹, Jim A. Bankson², Vikas Kundra¹, John C. Waterton³, Ed F. Jackson²

¹Radiology, MD Anderson Cancer Center, Houston, TX, USA; ²Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA; ³Astra-Zeneca, Alderley Park, Macclesfield, Cheshire, UK

The reproducibility of DCE-MRI parameters, as assessed by CV%, is in the range 13.4-16.6%, and appears better than for DCE-CT parameters (range 16.5-25.5%). The latter however may allow discrimination of perfusion and permeability, which the composite DCE-MRI parameter, Ktrans, does not. This may be of importance in future antiangiogenic targets.