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Abstract #4228

Reproducibility and Cross-Validation of DCE-MRI and DCE-CT Perfusion Parameters in a Rat Tumor Model

Chaan S. Ng1, Jim A. Bankson2, Vikas Kundra1, John C. Waterton3, Ed F. Jackson2

1Radiology, MD Anderson Cancer Center, Houston, TX, USA; 2Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA; 3Astra-Zeneca, Alderley Park, Macclesfield, Cheshire, UK

The reproducibility of DCE-MRI parameters, as assessed by CV%, is in the range 13.4-16.6%, and appears better than for DCE-CT parameters (range 16.5-25.5%). The latter however may allow discrimination of perfusion and permeability, which the composite DCE-MRI parameter, Ktrans, does not. This may be of importance in future antiangiogenic targets.