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Abstract #4236

Quantification of Absolute Concentration of Choline for Differentiation of Malignant, Benign and Normal Breast Tissues by In-Vivo Proton MR Spectroscopy.

Rani Gupta Sah1, Uma Sharma1, Rajinder Parshad2, Naranamangalam R. Jagannathan1

1Department of NMR and MRI Facility, All India Institute of Medcial Sciences, New Delhi, Delhi, India; 2Department of Sugical Disciplines, All India Institute of Medcial Sciences, New Delhi, Delhi, India

Absolute concentration of tCho was determined in breast tissue of 87 women including 52 patients with infiltrating ductal carcinoma, 15 benign and 20 normal volunteers using in-vivo proton MRS at 1.5 T. tCho signal was observed in all malignant and in 13/15 benign lesions and 8/20 normal volunteers. Concentration of tCho was 4.04 2.08 mmol/kg in malignant tumor which was significantly higher compared to benign (1.37 0.8 mmol/kg) and normal tissues (0.40 0.24 mmol/kg) suggesting that quantitative measurements provide unambiguous diagnosis of breast lesions. No significant difference was observed in tCho concentration between volunteers and benign lesions.