Abstract #4237

Statistical Analysis of Two Dimensional MR Spectroscopy Combined with Dynamic Contrast Enhanced MRI in Breast Cancer Detection

Xiaoyu Liu¹, Scott Lipnick¹, James Sayre¹, Nanette Debruhl¹, Aparna Singhal¹, Albert Thomas¹

¹Radiology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA

DCE MRI combined with 2D L-COSY can increase breast cancer detection specificity; 2D L-COSY can detect Choline which can be used as a biomarker to differentiate between malignant and benign tumors. 2D COSY of breast tissues showed several other metabolite and lipid ratios are significantly different between malignant tumor and benign tumor. A major goal of this work was to investigate the feasibility of using statistical analysis of 2D L-COSY combined with DCE MRI to classify malignant and benign breast tumors.