Meeting Banner
Abstract #4237

Statistical Analysis of Two Dimensional MR Spectroscopy Combined with Dynamic Contrast Enhanced MRI in Breast Cancer Detection

Xiaoyu Liu1, Scott Lipnick1, James Sayre1, Nanette Debruhl1, Aparna Singhal1, Albert Thomas1

1Radiology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA

DCE MRI combined with 2D L-COSY can increase breast cancer detection specificity; 2D L-COSY can detect Choline which can be used as a biomarker to differentiate between malignant and benign tumors. 2D COSY of breast tissues showed several other metabolite and lipid ratios are significantly different between malignant tumor and benign tumor. A major goal of this work was to investigate the feasibility of using statistical analysis of 2D L-COSY combined with DCE MRI to classify malignant and benign breast tumors.