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Abstract #4249

Evaluation of the Prostate After Treatment with High-Intensity Focussed Ultrasound (HIFU) Therapy Using Whole Prostate Diffusion Weighted Imaging (DWI) Analysis

Alex Chapman1, Nina Tunariu1, Veronica Morgan2, Nandita Desouza1

1Institute of Cancer Research, Sutton, Surrey, UK; 2Royal Marsden Hospital, Sutton, Surrey, UK

High intensity focussed ultrasound (HIFU) is increasingly being used to treat locally recurrent prostate cancer that has failed primary treatment. Nine patients were studied using a 1.5T Intera MR scanner with an endorectal receiver coil, before, after 6 weeks and after 6 months of HIFU treatment. Standard and diffusion-weighted images were acquired. ADCs and volumes for the whole gland were obtained for all time points. The results are suggesting that ADC at 6 weeks is an indicator of subsequent reduction in PSA. Earlier time points for measuring ADC may prove useful in predicting subsequent outcome and warrant further investigation.