Veronica Anna Morgan1, Sophie F. Riches2, Sharon Giles1, Nicholas Van As3,4, Chris Parker3,4, Nandita M. deSouza2
1Clinical Magnetic Resonance Group, Royal Marsden NHS Trust, Sutton, Surrey, UK; 2Clinical Magnetic Resonance Group, Institute of Cancer Research, Sutton, Surrey, UK; 3Academic Urology Unit, Royal Marsden NHS Trust, Sutton, Surrey, UK; 4Academic Urology Unit, Institute of Cancer Research, Sutton, Surrey, UK
Variability in fast and slow components of apparent diffusion coefficient (ADC) over whole prostate (WP) and tumor with time was investigated in patients on active surveillance. 32 patients studied at baseline and at a mean of 23months showed a significant reduction at TP2 compared to TP1 in tumor ADCoverall (5.2%; p=0.03) and ADCfast (4.3%; p=0.03) but not in ADCslow nor in any ADC components of WP. Those that progressed to radical treatment were primarily responsible for this effect and also demonstrated changes for WP in ADCoverall and ADCfast. For those that progressed on histology ADCoverall and ADCfast were significantly reduced compared to those that remained histologically stable. Changes in ADCfast over a 1-3yr time period show potential for monitoring disease progression in prostate cancer patients managed by active surveillance.