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Abstract #4255

High-Resolution Diffusion-Weighted Imaging for the Diagnosis of Prostate Cancer

Carolin Reischauer1, Bertram Jakob Wilm1, Johannes M. Frhlich2, Peter Boesiger1, Klaus U. Wentz1

1Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland; 2Guerbet AG, Scientific Affairs, Zurich, Switzerland

Several studies have demonstrated the benefit of diffusion parameters as markers for prostate cancer imaging. Most of these studies have applied single-shot spin-echo EPI due to its high SNR-efficiency and its insensitivity to motion artifacts. The thereby achievable resolution is limited by susceptibility-related artifacts and T2*-blurring. The present work shows that a spatially reduced FOV can achieve submilimeter in-plane resolution which enables improved evaluation of diffusion parameters in localized structures of the prostate.The method is tested in a clinical study with patients suspected to suffer from prostate cancer and the findings are compared with a control group and with histopathology.