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Abstract #4270

Improving Spectral Resolution of Proton MRSI by Deconvolving Field Inhomogeneities

Zhengchao Dong1,2, Bradley Peterson1,2

1Columbia University, New York, NY, USA; 2New York State Psychiatric Institute, New York, NY, USA

The resolution of in vivo 1H MRSI spectra is often degraded by magnetic field inhomogeneities, making the quantification of metabolites with overlapping spectral peaks difficult or impossible. In this work, a novel post-processing method is proposed that can significantly ameliorate the deleterious effects of magnetic field inhomogeneities, thereby enhancing the resolution of MRSI spectra. The method is demonstrated and validated using phantom and in vivo experiments. The results show that this method not only enhances spectral resolution, but it also improves the lineshape of MRSI spectra.