Tom WJ Scheenen1, Jurgen J. Ftterer1, Elisabeth Weiland2, Jaoping Lu3, Barbara Holshouser4, Paul van Hecke5, Marc Lemort6, Christian M. Zechmann7, Heinz-Peter Schlemmer8, Geert M. Villeirs9, Jelle O. Barentsz1, Stefan O. Roell2, Arend Heerschap1
1Radiology (667), Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; 2Siemens Healthcare; 3Shanghai Changhai Hospital, China; 4Loma Linda University Medical Centre, USA; 5University Hospital, Katholieke Universiteit Leuven, Belgium; 6the Bordet Institute, Belgium; 7German Cancer Research Center DKFZ, Germany; 8University of Tuebingen, Germany; 9Ghent University Hospital, Belgium
Within the IMAPS study (International Multi-Centre Assessment of Prostate MR Spectroscopy) the reproducibility of 3D 1H-MRSI at a field strength of 1.5T was evaluated by repeated measurements of patients and healthy young volunteers. Ten subjects were measured twice on 2 different days. Selected voxels of the same location in both measurements were fit automatically and visually inspected for quality control. The bias and corresponding standard deviation of a Bland Altman analysis of the (choline+creatine)/citrate ratio of these voxels were calculated. The standard deviation of differences in repeated measurements was similar to the standard deviation of non-cancer peripheral zone tissue in patients with prostate cancer.
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