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Abstract #4285

Reproducibility of 3D 1H MR Spectroscopic Imaging of the Prostate at 1.5T.

Tom WJ Scheenen1, Jurgen J. Ftterer1, Elisabeth Weiland2, Jaoping Lu3, Barbara Holshouser4, Paul van Hecke5, Marc Lemort6, Christian M. Zechmann7, Heinz-Peter Schlemmer8, Geert M. Villeirs9, Jelle O. Barentsz1, Stefan O. Roell2, Arend Heerschap1

1Radiology (667), Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; 2Siemens Healthcare; 3Shanghai Changhai Hospital, China; 4Loma Linda University Medical Centre, USA; 5University Hospital, Katholieke Universiteit Leuven, Belgium; 6the Bordet Institute, Belgium; 7German Cancer Research Center DKFZ, Germany; 8University of Tuebingen, Germany; 9Ghent University Hospital, Belgium

Within the IMAPS study (International Multi-Centre Assessment of Prostate MR Spectroscopy) the reproducibility of 3D 1H-MRSI at a field strength of 1.5T was evaluated by repeated measurements of patients and healthy young volunteers. Ten subjects were measured twice on 2 different days. Selected voxels of the same location in both measurements were fit automatically and visually inspected for quality control. The bias and corresponding standard deviation of a Bland Altman analysis of the (choline+creatine)/citrate ratio of these voxels were calculated. The standard deviation of differences in repeated measurements was similar to the standard deviation of non-cancer peripheral zone tissue in patients with prostate cancer.