Abstract #4286

Comparison Between Internal and External Validation of in Vivo 31P MRS Quantification

Jon Dudley¹, Wen-Jang Chu^2,3, Xin Wang¹, Matthew M. Norris¹, Jing-Huei Lee^1,3

¹Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA; ²Psychiatry, University of Cincinnati, Cincinnati, OH, USA; ³Center for Imaging Research, University of Cincinnati, Cincinnati, OH, USA

Internal references are commonly used in in vivo MRS research. However, an internal reference for 31P MRS study may not be practical. This works is to investigate if an external reference can be reliable method for 31P MRS data by comparing its result with that obtained by an internal reference from 1H MRS data. The results showed that there is a strong correlation between these two approaches indicating that an external reference can be a reliable method.