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Abstract #4300

Exploration of the Effect of Whole Body Ionising Radiation Exposure on the Metabolism of Renal Tissue in Mice Using High Resolution 1H NMR Spectroscopy

Poonam Rana1, Ritika Agarwal1, Ahmad Raza Khan1, Shubhra Chaturvedi2, Rajendra Prasad Tripathi, Subash Khushu1

1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 2Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, India

Ionising radiation has noticeable effect on physiology of the living systems. The present study was conducted to assess radiation induced changes in kidney tissue of mice after radiation dose of 5Gy and monitor changes after 5 and 25 days of irradiation using high resolution NMR spectroscopy. Significant changes were observed only after 25 days of exposure in protein/amino acid metabolism, energy metabolism and membrane structure alteration as shown by increased free amino acids, lactate, choline and myo-inositol levels. This study could be helpful for identification of potential biomarkers associated with radiation induced changes and may find applications in biological dosimeters.