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Abstract #4301

Increasing Indices of Bile Constituents Following Decompression Therapy Are Indicators of Restorative Function of Hepatocytes: 1H and 31P NMR Studies<

Pratima Tripathi1, Lakshmi Bala1, Gourdas Choudhuri2, C. L. Khetrapal1

1CBMR, Centre of Biomedical Magnetic Resonance, Lucknow, Uttar Pradesh, India; 2Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

1H and 31P NMR analysis on bile, obtained serially following drainage from nineteen patients with extrahepatic malignant biliary obstruction were performed for chief biliary constituents. Based upon absence or presence of cholangitis, patients were classified in two groups. Before drainage median indices of biliary constituents were undetectable in both groups but, recovery following decompression was observed by day 1, with more significance in patients with cholangitis compared to without cholangitis. However, values significantly increased following one week of drainage (P<0.05) in both groups. Suppressed function of transporters during cholestasis is restored following decompression leading to the appearance of biliary constituents.