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Abstract #4309

Metabolism of Abnormal and Normal Colonic Mucosa of Patients with Ulcerative Colitis (UC) and Crohns Disease (CD): An In-Vitro Proton MRS Study

Uma Sharma1, Rajiv R. Singh1, Vineet Ahuja2, Govind K. Makharia2, Naranamangalam R. Jagannathan1

1Department of NMR and MRI Facility, All India Institute of Medcial Sciences, New Delhi, Delhi, India; 2Department of Gasteroenterology, All India Institute of Medcial Sciences, New Delhi, Delhi, India

Metabolism of normal and abnormal colonic mucosa of patients with ulcerative colitis (UC) and Crohns disease (CD) was investigated using in-vitro proton MRS. Significantly lower concentration of Lac, Cr/PCr ATP, GPC, Cho and mI was observed in normal and abnormal mucosa of UC and CD compared to controls indicating lower energy status. However, concentrations were similar for the normal and abnormal area of mucosa in patients. Loss of cellular energy may affect various energy dependent processes including electrolyte exchange, biosynthesis of macromolecules and detoxification. These metabolic abnormalities in normal mucosa indicate the progression of disease in UC and CD.