Metabonomic Differentiation of Long-Term Dietary Intervention with NMR Spectroscopy of Human Urine Samples

Jingjing Xu¹, Shuhui Cai¹, Jiyang Dong¹, Xuejun Li², Zhong Chen¹

The biochemical effects of omnivorous and vegetarian diets in human were investigated using NMR-based metabonomics on human urines. Different effects can be discriminated clearly according to the score plot of principle component analysis. Compared to the omnivorous group, urinary excretion of creatine, creatinine, TMAO, taurine, methylhistidine, glucose and DMA decreased following plant-based diet, with relatively increase in the level of 3-hydroxybutyrate, citrate and hippurate. All of the results show that different dietary components have great influences on the human metabolic phenotypes and the associations between food intake and metabolic pathway need further exploration.