In Vivo Fourier Shifted Two-Dimensional Zero-Quantum Coherence 1H NMR Spectroscopy of Glutamate and Glutamine

Sarah Rebecca Snyder¹, Sebastian Schmitter¹, Armin Nagel¹, Peter Bachert¹

Previously, it has been shown that glutamate can be distinguished from glutamine when their zero-quantum coherence (ZQC) modulation frequencies as well as their chemical shift values are used as identification parameters in 2D spectra. However, acquisition times for such spectra exceeded four hours. We now show that by recording 2D spectra, which are undersampled along the ZCQ modulation frequency axis and then applying a Fourier Shift, glutamate can be distinguished from glutamine in 50 minutes. We demonstrate this on a healthy volunteer using a 3 Tesla whole-body MR tomograph and show that there is no loss in resolution.