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Abstract #4321

Detection of Glutathione with High Precision in the Anterior Cingulate Using Short TE 1H MRS at 3T

Ralf Mekle1,2, Giulio Gambarota1, Tanja Teichmann3, Kim Q. Do3, Rolf Gruetter1,4

1Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Federale de Lausanne, Lausanne, Vaud, Switzerland; 2Department of Radiology, University of Lausanne, Lausanne, Vaud, Switzerland; 3Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University - CHUV, Lausanne, Switzerland; 4Departments of Radiology, Universities of Lausanne and Geneva, Lausanne and Geneva, Vaud, Switzerland

A neurochemical profile including the antioxidant glutathione (GSH) was measured with high precision using MRS for the application to schizophrenia. Localized proton spectra were acquired in the anterior cingulate for N=4 volunteers using the spin echo full intensity acquired localized (SPECIAL) MRS technique. Scans were performed on a clinical platform using a TEM volume coil at 3T. Results yielded excellent data quality and detection of GSH with mean Cramer-Rao lower bound (CRLB) of 9%. Fourteen additional metabolites were quantified with CRLBs below 20%. Detection precision was sufficiently high for treatment monitoring of schizophrenic patients after administration of therapeutic drugs.