Abstract #4337

A Comparison Between Simulated and Experimental Basis Sets for the Analysis of Short-Echo In-Vivo MRS Data at 1.5T

Martin Wilson^1,2, Nigel P. Davies^1,2, Yu Sun^2,3, Kal Natarajan², Theo N. Arvanitis^2,3, Andrew C. Peet^1,2

¹Cancer Sciences, University of Birmingham, Birmingham, West Midlands, UK; ²Oncology, Birmingham Childrens Hospital Foundation Trust, Birmingham, West Midlands, UK; ³School of Electronic, Electrical and Computer Engineering, University of Birmingham, Birmingham, West Midlands, UK

The use of a simulated basis set for the analysis of 1H short-echo MRS data offers a number of advantages over an experimental basis set. One main advantage is that simulated basis sets can be easily regenerated for a particular echo-time or field strength without requiring hours of scanner time. In this study a comparison is performed between the metabolite quantities estimated by LCModel using simulated and experimental basis. A good correlation is seen between both methods suggesting that little bias is introduced by using a simulated basis set.