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Abstract #4350

Computer Simulation of Breast Compression Based on Segmented Breast and Fibroglandular Tissues on MRI

Tzu-Ching Shih1,2, Dongxu Liu3, Jeon-Hor Chen1,4, Lizhi Sun3, Ke Nie1, Huiming Yin5, Daniel Chang1, Orhan Nalcioglu1, Min-Ying Lydia Su1

1Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, USA; 2Department of Medical Radiology Technology, China Medical University, Taichung, Taiwan; 3Department of Civil and Environmental Engineering, University of California, Irvine, CA, USA; 4Department of Radiology, China Medical University Hospital, Taiwan; 5Department of Civil Engineering and Engineering Mechanics, Columbia University, New York, NY, USA

We developed a 3D modeling analysis to investigate the impact of breast compression on mammographic density. MRI provides 3D information of breast and fibroglandular tissue for creating a 3D model. The volume mesh was created using the ANSYS ICEM CFD software, then the MSC Marc software was used to simulate the breast compression deformation. The results showed that the density variation between 40% to 60% compression level was around 8% on CC view, and 12% on MLO view. The simulation model can be applied to gain more in-depth understanding about the dependence of mammographic density on the potential technical factors.