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Abstract #4380

Acute Liver Failure Studied by Hyperpolarized 1,4-13C2-Fumarate in CCl4 Injured Rat Liver

Rene in 't Zandt1, Magnus Karlsson1, Anna Gisselsson1, Pernille Rose Jensen1, Georg Hansson1, Mathilde Lerche1

1Imagnia AB, Malm, Sweden

We have developed a diagnostic marker - hyperpolarized 1,4-13C2-fumarate, which takes advantage of the technique dynamic nuclear polarization for magnetic resonance imaging (DNP-MRI). This marker allows real-time metabolic studies of a TCA-cycle intermediate, 13C-malate. With this marker we have investigated the metabolism in the liver of CCl4 treated rats.