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Abstract #4388

PASADENA Hyperpolarization: Instrumentation and Preparation of Tracers for in Vivo Application

Jan-Bernd Hvener1,2, Eduard Chekmenev1,3, Larry Robertson1, Kent Harris1, Thao Tran1, William Perman4, Brian Ross1, Pratip Bhattacharya1

1Enhanced Magnetic Resonance Laboratories, Pasadena, CA, USA; 2Medical Physics in Radiology, DKFZ, Heidelberg, Germany; 3California Institute of Technology, Pasadena, CA, USA; 4St. Louis University, School of Medicine, St. Louis, USA

In the dawn of hyperpolarization for biomedical application, the question of suitable instrumentation arises. PASADENA is presently installed only in few places, possibly because only few molecules and no instrumentation is available. We present a polarizer for the reliable hyperpolarization various molecules, including novel molecules 1-13C, 2,3-D2 Succinate (Suc) and TFPP, a target specific agent. Reproducibility and yield of hyperpolarized Suc using the new apparatus was determined to = (0.064 0.02), t = (33 0.5) s after sample production. By measurement of T1(4.7 T) = (39.6 0.6) s, the nascent level was estimated to  15 %.