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Abstract #4389

Optimization of 89Y DNP

Zoltan Kovacs1, Steven Reynolds2, Matthew E. Merritt3,4

1AIRC, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Oxford Instruments Molecular Biotools, Oxford, UK; 3Advance Imaging Research Center, UT Southwestern Med. Center, Dallas, TX, USA; 4Radiology, UTSW Medical Center, Dallas, TX, USA

Metabolically sensitive imaging agents promise to transform the diagnostic capabilities of MRI. Yttrium-89 is an attractive nucleus for DNP studies due to its extremely long T1. Yttrium is isostructural to gadolinium, and so could serve as the basis for a variety of contrast agents using previously developed ligands but with the added capability of direct detection. Yttrium DNP is optimized in this study and a new method of polarization is suggested.