Abstract #4411

Dynamics and Distributions of Temperature Changes During Pharyngeal Selective Brain Cooling by 1H CSI

Daniel Coman^1,2, Hubert K.F. Trubel^3,4, Peter Herman^1,5, Fahmeed Hyder^2,6

¹Department of Diagnostic Radiology, Yale University, New Haven, CT, USA; ²Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, USA; ³Bayer HealthCare Research Center, Wuppertal, Germany; ⁴Department of Pediatrics, HELIOS-Klinikum Wuppertal, University Witten/Herdecke, Wuppertal, Germany; ⁵Semmelweis University, POB 448, H-1446, Budapest, Hungary; ⁶Department of Diagnostic Radiology and Biomedical Engineering, Yale University, New Haven, CT, USA

Pharyngeal selective brain cooling (pSBC) has been suggested a more suitable alternative to whole body cooling to decrease brain temperature. Temperature distributions in rat brain can be obtained within minutes by using a new exogenous temperature-sensitive probe, TmDOTMA^-. The pharyngeal brain cooling rate constants and the recovering rate constants were calculated from the temperature variation over time. The recovering rate constants show a distribution which is slightly more dispersed than that of the cooling rate constants. Our results indicate that pSBC rate constants are tightly dependent on the local net heat contribution, measured indirectly by the recovering rate constants.