Wanyong Shin1, Hong Gu1, Yihong Yang1
1Neuroimaging Research Branch, National Institute on Drug Abuse, Baltimore, MD, USA
A fast T1 measurement sequence using inversion recovery Look-Locker echo-planar imaging at steady state (IR LL-EPI SS) is presented. Delay time for a full magnetization recovery is not required in the sequence, saving acquisition time significantly. Imaging parameters were optimized to minimize the bias from the imperfection of excitation pulses and to maximize the accuracy and reliability of T1 measurements. IR LL-EPI SS method preserves similar accuracy and reliability as conventional Look-Locker echo-planar imaging, while saving 20% acquisition time. Quantitative T1 mapping with 114 mm3 resolution and whole brain coverage (28 slices) can be collected in approximately 4 minutes.