Abstract #4476

Correlation of Potential Myelin Measures from Quantitative Magnetisation Transfer (QMT) and Multi-Component Driven Equilibrium Single Pulse Observation of T1 and T2 (McDESPOT)

Rebecca Sara Samson¹, Sean C L Deoni², Claudia A M Wheeler-Kingshott¹

¹Department of Neuroinflammation, UCL Institute of Neurology, London, UK; ²Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK

It has previously been suggested that both the restricted proton fraction (f_b) measured from quantitative Magnetisation Transfer (qMT) and myelin water fraction (f_m) from multi-component relaxometry are related to myelin content in the brain. Multi-Component Driven Equilibrium Single Pulse Observation of T₁ and T₂ (mcDESPOT) is a promising alternative to spin-echo multi-component T₂ analysis. This pilot study investigates the correlation of f_m measured via the mcDESPOT technique with f_b at 1.5T in white and grey matter in three healthy volunteers.