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Abstract #4477

An Improved Empirical Solution for Describing Chemical Exchange Saturation Transfer (CEST) MRI

Phillip Zhe Sun1

1Department of Radiology, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA

An empirical solution based on a 2-pool exchange model has been proposed to describe CEST MRI, providing tremendous insights for quantitative CEST imaging. Nevertheless, the empirical solution is only a first order approximation, and susceptible to non-negligible errors when quantifying CEST imaging of fast exchange groups under practical conditions (i.e. intermediate RF powers). To properly guide future development of more sensitive exogenous PARACEST/LIPOCEST agents, we modified the simplistic empirical equation with a second order correction term, which showed good agreement with numerical simulation.